Jesse Wiley

The Wiley Lab uses a combination of human induced pluripotent stem cell (hiPSC) derived neuronal models (monolayer and organoids) and in silico computational bioinformatics approaches to study Alzheimer’s disease. The active hypothesis of the lab is that bidirectional communication between synaptic signaling and mitochondrial bioenergetic state influences the epigenetic regulation necessary for homeostatic regulation of both synapse and mitochondria. We predict that if this homeostatic regulation breaks down, AD pathogenesis progresses as an abnormal form of aging, invoking activation of the adaptive and innate immune systems. Our ultimate goal is to identify novel and pharmacologically targetable points of intervention and cultivate novel therapeutic approaches to counter neurodegeneration in AD.