Research Overview —
Much of the effort of current Alzheimer’s Disease (AD) research has been dedicated to identifying useful biomarkers for AD diagnosis and risk assessment. Structural and functional brain connectivity have emerged as potential biomarkers of AD, and may inform the pathophysiology of dementia. Connectivity changes over the disease course may help bridge the molecular view of AD as a disorder of abnormally aggregated proteins with the clinical understanding of AD as a collection of cognitive symptoms. My project aims to characterize the nature of functional connectivity changes in aging and dementia across diverse cohorts, and to specifically relate these changes to neurometabolism and metabolic risk factor.
Education —
- B.S. in Biochemistry, University of Kansas, awarded 2018
- B.A. in Human Biology, University of Kansas, awarded 2018
- B.A. in Psychology w/ Honors, University of Kansas, awarded 2018
Publications —
Honea RA, John CS, Green ZD, Kueck PJ, Taylor MK, Lepping RJ, Townley R, Vidoni ED, Burns JM, Morris JK (February 2022) Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers. Alzheimers Dement PMID: 35128029
Morris JK, McCoin CS, Fuller KN, John CS, Wilkins HM, Green ZD, Wang X, Sharma P, Burns JM, Vidoni ED, Mahnken JD, Shankar K, Swerdlow RH, Thyfault JP. (September 2021) Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle. Function. PMID: 34661111
Green ZD, John CS, Kueck PJ, Burns JM, Perry M, Donald J, Mahnken JD, Honea RA, Vidoni ED, Morris JK. (August 2021) Rationale and methods to characterize the acute exercise response in aging and Alzheimer's Disease: the AEROBIC pilot study. Contemp Clin Trials. PMID: 34051350.
Morris JK, John CS, Green ZD, Wilkins HM, Wang X, Kamat A, Swerdlow RS, Vidoni ED, Petersen ME, O'Bryant SE, Honea RA, Burns JM (November 2020) Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease. Front Neurosci. PMID: 33328877
Morris JK, Piccolo BD, John CS, Green ZD, Thyfault JP, Adams SH. (2019) Oxylipin Profiling of Alzheimer's Disease in Nondiabetic and Type 2 Diabetic Elderly. Metabolites. PMID: 31491971
Valdivieso-Mora, E., Ivanisevic, M., Shaw, L. A., Garnier-Villarreal, M., Green, Z. D., Salazar-Villanea, M., Moncada-Jiménez, J., & Johnson, D. K. (2018) Health-Related Quality of Life of Older Adults in Costa Rica as Measured by the Short-Form-36 Health Survey. Gerontology & Geriatric Medicine. PMID: 30046646
Presentations —
Zachary D. Green, David K. Johnson. (April 2017) Cognitive Differences Between Older Adults in Healthy Cohort of Costa Ricans & Kansans. KU Symposium for Undergraduate Psychology Engagement & Research, Lawrence, Kansas. Poster presentation.
M. Ivanisevic, E. Valdivieso, M. Garnier, Z. Green, R. Smart, D. Johnson. (2017) Factor Structure of the Short-Form Health Survey (SF-36) in a Sample of Older Adults in Costa Rica. Innovation in Aging, IAGG 2017 World Congress, San Francisco, CA. Poster presentation.
Green, Zachary, David K. Johnson. (2017) “Early Steps of Alzheimer's Disease Prevention: Exploring Functional Regulation in Older Adults”. University of Kansas’ Undergraduate Research Symposium, Lawrence, Kansas. Oral Presentation.
Green, Zachary, David K. Johnson. (2017). “Contributions of Social Factors to Cognitive Differences in Older Adults from Kansas & Costa Rica”. Hall Center’s Undergraduate Research Seminar, Lawrence, Kansas. Oral Presentation.
Morris, J.K. John, C.S., Lott, J., Green, Z.D., Kamat, A., Wilkins, H.M., Wang, X., Weidling, I.W., Swerdlow, R.H., Thyfault, J.P., Vidoni, E.D., and J.M. Burns. (July 2018) Alzheimer’s disease subjects exhibit impaired glucose metabolism following a mixed meal. Alzheimer’s Association International Conference, Chicago, IL. Poster presentation.
Green, Z.D., Morris, J.K., John, C.S., Kueck, P.J. (April 2021) Using brain biomarkers to probe cerebral responsiveness to exercise; the AEROBIC study. University of Kansas Medical Center Student Research Forum, Kansas City, KS. Oral presentation.
Zachary D. Green, Robyn A Honea, Eric D. Vidoni, Jeffrey M. Burns, and Jill K Morris (July 2021) Functional Connectivity is altered by APOE4 Carrier Status in Cognitively Healthy Older Adults. Alzheimer’s Association International Conference, Denver, CO. Poster presentation.
Zachary D. Green, Robyn A Honea, Eric D Vidoni, Jeffrey M. Burns, and Jill K Morris (July 2021) Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease. Alzheimer’s Association International Conference, Denver, CO. Poster presentation.
Honea, R.A., Green, Z.D., John, C.S., Kamat, A., Kueck, P. Taylor, M., Vidoni, E.D., Burns, J.M., and J.K. Morris (July 2021) Increased structural and neuropathological decline occur with worsening fasting glucose in individuals at risk for Alzheimer’s Disease. Alzheimer’s Association International Conference, Denver, CO. Poster presentation.
Zachary D. Green, Jill K. Morris, Paul Kueck, Casey John, Eric Vidoni, Jeffrey Burns (April 2022) Relationship between clinician-rated amloid status and traditional AD biomarkers in cognitively healthy older adults. University of Kansas Medical Center Student Research Forum, Kansas City, KS. Oral presentation.
Awards and Honors —
Awards
- KU University Honors
- KU Psychology Honors w/ Distinction
- KU Research Experience Certification
- KU Global Awareness Certification w/ Distinction
- KUMC 3-Minute Thesis Finalist (2021)
- KUMC 2021 SRF Platform I Oral, 1st Place
- KUMC 2022 SRF Platform K Oral, 1st Place
- KUMC 2022 SRF Overall Best Presentation
- KUMC 2022 SRF Paul R. Schloerb MD Clinical Research Award
Fellowships
- KUMC Biomedical Research Training Program
- Kansas T32 Training Program in Neurological and Rehabilitation Sciences