Research Overview —
I aim to improve the prediction accuracy of Alzheimer’s Disease (AD) polygenic scores (PGS) by focusing on mitochondrial dysfunction and its interaction with cardiometabolic risk factors for dementia in a large diverse U.S. cohort in the All of Us Research Program. Specifically, I will compare the prediction accuracy of whole-genome versus mitochondrial-specific PGS across ancestries and socioeconomic backgrounds. I will also explore how mitochondrial genetic risk modifies the effect of twelve validated modifiable risk factors where I hypothesize an outsized amplified risk of dementia in individuals with both high polygenic risk and cardiometabolic risk factors such as hypertension or type II diabetes.
Publications —
Farrukh, R., Milani, S., Woods, J., Adenij, E., Farooq, A., Mansel, C., Burns, J., Hsu, W. (2024) Unifying Interpretability and Explainability for Alzheimer’s Disease Progression Prediction. arXiv. https://doi.org/10.48550/arXiv.2406.07777
Gratuze M, Schlachetzki J, Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O’Brien S, Pasillas M, Lee C, Manis M, Colonna M, Harari O, Glass C, Ulrich J, Holtzman D (2022) TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron; 111(2):202-219
Troutwine B, Strope T, Franczak E, Lysaker C, Hamid L, Mansel C, Stopperan J, Gouvion C, Haeri M, Swerdlow R, Wilkins H (2022) Mitochondrial function and Aβ in Alzheimer's disease postmortem brain. Neurobiology of Disease; 171:105781
Mansel C, Sarnataro R, Liu P (2021) A critical evaluation of the National Innovation Accelerator programme: comparing eHealth and medical device-based innovations. British Journal of Healthcare Management; 27(4):1-10
Fross S, Mansel C, McCormick M, Vohra BPS (2021) Tributyltin alters calcium levels, mitochondrial dynamics, and activates calpains within dorsal root ganglion neurons. Toxicological Sciences; 180(2):342-355.
Mansel C, Fross S, Rose J, Dema E, Mann A, Hart H, Klawinski P, Vohra BPS (2019) Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells. Neurotoxicology and Teratology; 72:58–70
Pottorf T, Mann A, Fross S, Mansel C, Vohra BPS (2018) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure. Neurochemistry International; 121:86-97
Presentations —
Mansel C, Mazzotti D, Townley R, Sardiu M, Swerdlow R, Honea R, Veatch O; Alzheimer’s Disease Heterogeneity is Driven by Mitochondrial Genetic Risk. 2024 American Society for Human Genetics Annual Meeting
Mansel C, Mazzotti D, Veatch O; A Polygenic Risk Score for Alzheimer’s Disease in the All of Us Research Program. 2024 KUMC Internal Medicine Research Day.
Mansel C; A Polygenic Risk Score for Alzheimer’s Disease in the All of Us Research Program. 2024 Brain Health Training Program Retreat Oral Presentation
Mansel C, Mazzotti D, Townley R, Sardiu M, Swerdlow R, Honea R, Veatch O; Problem History Clusters in the National Alzheimer’s Coordinating Centers Database. 2024 Alzheimer’s Association International Conference.
Mansel C; Problem History Clusters in the National Alzheimer’s Coordinating Centers Database. 2024 Innovations in Design, Analysis, and Dissemination (IDAD): Frontiers in Biostatistics & Data Science Oral Presentation.
Veatch O, Dutta S, Mansel C, Townley R, Sardiu M, Honea R; Using machine learning of neuroimaging patterns combined with mitochondrial genomics to predict maternal inheritance of Alzheimer’s disease. 2023 Alzheimer’s Association International Conference. https://doi.org/10.1002/alz.083076
Mansel C; Defining the Clinical Heterogeneity in Alzheimer’s Disease: A Data-Driven Approach. 2023 Brain Health Training Program Retreat Oral Presentation
Mansel C, Fross S, Vohra BPS (2020) Lead Exposure Alters the Neurogenic Potential of Pluripotent Stem Cells. Society of Toxicology Annual Meeting
Mansel C, Vohra BPS (2019) Tributyltin caused neurodegeneration in mouse enteric neurons. Heartland Undergraduate Biochemistry Forum
Mansel C, Tsai P (2019) Leveraging multi-fiber photometry to illuminate circuit dynamics across the mouse brain. UTSW Summer Intern Symposium
Awards and Honors —
T32 Graduate Scholar, Brain Health Training Program, T32 AGO78114, P30 AGO72973, 01/01/25-12/31/26
Graduate Scholar, Brain Health Training Program (T32), KUMC (2023-25)
KUMC Student Organization of the Year, Health Career Collaborative (2023)
William Jewell College Honors (2020)
St. Catherine’s College Book Award, Oxford University (2019)
Pryor Leadership Fellow, William Jewell College (2017-2020)
Wakonda Spirit Award, Ozarks Regional YMCA (2017)
William Jewell College Oxbridge Honors Scholar (2016-2020)