Research Overview —
One possible reason for the failure of clinical trials in Alzheimer’s Disease (AD) is that they generally treat all AD patients the same. My project uses unsupervised machine learning to describe sub-types of AD using clinical databases and the electronic health record (EHR). Because family history is known to confer increased risk for AD, my project also seeks to use data-driven approaches to uncover possible AD sub-types that are associated with specific genetic risk measures.
Publications —
Gratuze M, Schlachetzki J, Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O’Brien S, Pasillas M, Lee C, Manis M, Colonna M, Harari O, Glass C, Ulrich J, Holtzman D (2022) TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron; 111(2):202-219
Troutwine B, Strope T, Franczak E, Lysaker C, Hamid L, Mansel C, Stopperan J, Gouvion C, Haeri M, Swerdlow R, Wilkins H (2022) Mitochondrial function and Aβ in Alzheimer's disease postmortem brain. Neurobiology of Disease; 171:105781
Mansel C, Sarnataro R, Liu P (2021) A critical evaluation of the National Innovation Accelerator programme: comparing eHealth and medical device-based innovations. British Journal of Healthcare Management; 27(4):1-10
Fross S, Mansel C, McCormick M, Vohra BPS (2021) Tributyltin alters calcium levels, mitochondrial dynamics, and activates calpains within dorsal root ganglion neurons. Toxicological Sciences; 180(2):342-355.
Mansel C, Fross S, Rose J, Dema E, Mann A, Hart H, Klawinski P, Vohra BPS (2019) Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells. Neurotoxicology and Teratology; 72:58–70
Pottorf T, Mann A, Fross S, Mansel C, Vohra BPS (2018) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure. Neurochemistry International; 121:86-97
Presentations —
Mansel C, Fross S, Vohra BPS (2020) Lead Exposure Alters the Neurogenic Potential of Pluripotent Stem Cells. Society of Toxicology Annual Meeting
Mansel C, Vohra BPS (2019) Tributyltin caused neurodegeneration in mouse enteric neurons. Heartland Undergraduate Biochemistry Forum
Mansel C, Tsai P (2019) Leveraging multi-fiber photometry to illuminate circuit dynamics across the mouse brain. UTSW Summer Intern Symposium
Awards and Honors —
KUMC Student Organization of the Year, Health Career Collaborative (2023)
William Jewell College Honors (2020)
St. Catherine’s College Book Award, Oxford University (2019)
Pryor Leadership Fellow, William Jewell College (2017-2020)
Wakonda Spirit Award, Ozarks Regional YMCA (2017)
William Jewell College Oxbridge Honors Scholar (2016-2020)
Graduate Scholar, Brain Health Training Program (T32), KUMC (2023-25)