- M.S., Obstetrics and Gynecology, China Medical University, Shenyang, China (2014)
- B.S., Clinical Medicine, China Medical University, Shenyang, China (2012)
- How estrogen signaling and ApoE polymorphisms interact to modulate energy metabolism in neuronal cell models
- Bachelor of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal (2016)
- Elucidation of role of Apolipoprotein J in Alzheimer's Disease
- Bachelor of Pharmacy, University of Jordan, Amman, Jordan (2016)
- Behavior pharmacology
- Neurodegenerative disorders
- Ph.D., Bioscience and Biotechnology, Konkuk University, Seoul, South Korea (2011)
- M.S., Food and Nutirtion, Sungshin Women’s University, Seoul, South Korea (2001)
- B.S., Food and Nutirtion, Sungshin Women’s University, Seoul, South Korea (1999)
- Roles of PTMs of apolipoproteins in the development of late-onset Alzheimer’s disease
- M.S., Pharmacology & Toxicology, University of Kansas, 2019
- B.S., Pharmacy, Nanavati College of Pharmacy, Mumbai University, India, 2016
Assistant Specialist, Univ. of California San Francisco
The primary focus of research in our laboratory is directed toward a molecular understanding of sex differences and interactions of sex and genetic susceptibility in the development of late-onset Alzheimer’s disease (LOAD). Our current research involves two lines of investigation: 1) the mechanisms underlying sex and apolipoprotein E (ApoE) polymorphisms (ApoE2, ApoE3, ApoE4)-mediated differential risks for LOAD; and 2) the roles of apolipoprotein J (ApoJ) isoforms (cytosolic vs nuclear) and regulation by sex hormones in the brain under both normal and neurodegenerative conditions. The goals of these investigations are to identify the key molecular pathways and biomarkers for translational development of therapeutic strategies aimed at AD prevention, risk reduction, and early intervention.
We are also interested in exploring the mechanisms involved in the development of perimenopausal depression. Women are more than 2.5 times more likely than men to experience major depression, with most cases occurring during perimenopause. We are currently investigating our hypothesis that perturbation of estrogen receptor beta (ERbeta) activity resulting from perimenopause leads to deficits in BDNF—5-HT duo signaling that results in decreased plasticity of brain to adapt in response to environmental stressors and thus increased vulnerability for the onset of depression.
The state-of-the-art techniques used in our studies include: primary neuronal cultures, transgenic rodent models, qRT-PCR gene arrays, 2D proteomics, bioinformatics, mitochondrial biochemistry, behavioral modeling, and computational simulations, in addition to other general methods commonly used in molecular and cellular biological, pharmacological, and drug design and discovery research.
Currently Funded Projects:
NIH: Sporadic Alzheimer’s Disease: A Bioenergetic Etiology?
NIH: ApoE, Energy, and Synaptic V-ATPase
NIH: Role of Clusterin in Brain Mitochondria
J.R. and Inez Jay Fund: ApoE2 as a Therapeutic Shield Against Alzheimer’s Disease: A Proof-of-Concept Study
- Postdoctoral, Bejing Institute of Pharmacology and Toxicology, Bejing, China (2002)
- Ph.D., Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang Shi, Liaoning Sheng, China (1999)
Liqin Zhao’s research focuses on brain aging, neurodegenerative (with an emphasis on Alzheimer’s disease) and neuropsychological disorders (with an emphasis on depression) that are investigated at both mechanistic and translational levels. Zhao has authored more than 50 research articles, 80 conference presentations, six patents (four granted), and served as an editor/reviewer for more than 30 medical research journals. She and her research have been featured by multiple news outlets including USC News, USC Trojan Family Magazine, USC Pharmacy Magazine, KU News, KU Chancellor’s Report, Lawrence 6News, Women’s Brain Health Initiative, Nature Medicine, and Alzheimer’s Association under Spotlight on Researchers Dedicated to Alzheimer’s.
At the KU School of Pharmacy, in addition to directing a research lab and training students on their research activities, Zhao teaches in both Pharm.D. and graduate (M.S. and Ph.D.) programs, with a teaching focus on the nervous system including both autonomic and central nervous system. Dr. Zhao also directs the “Beyond the Lab” career development program.