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Oliver L'Esperance

Graduate Student
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Summary

Educational Background

  • 2017 BS in Neurobiology, University of Kansas

Research

My research focuses on memory impairment from neural damage. As an undergraduate, I worked in Dr. David Jarmolowicz's Applied Behavioral Sciences lab at the University of Kansas to characterize poor delay discounting in rats following 5-fluorouracil chemotherapy. We demonstrated that mitochondrial-protective heat shock protein activation during chemotherapy by small molecule drug KU32 was sufficient to prevent chemo-induced delay discounting impairment. My current research at KU with Dr. Jai Subramanian's Pharmacy & Toxicology lab centers on visualizing memory consolidation in the mouse primary visual cortex via activity-dependent neural tagging and repeated in vivo two-photon microscopy. We intend to use this system early in an animal model of Alzheimer's Disease to study excitation/inhibition balance homeostasis at synapse resolution during visual memory formation and recognition. My additional interests include the role of reward processing in depression, anxiety, PTSD, and OCD.


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