I started my research program on the role of lipid rafts as compartments for signaling via neurotrophin receptors. As changes in neurotrophin signaling are known to contribute to nerve degeneration in diabetic neuropathy, we extended our work to diabetic animal and cell culture models, which is the current thrust in the lab.
The specific aims of my research are designed to determine how the Msr system affects the function and expression of other proteins as well as to evaluate the role of methionine oxidation in the progression of oxidative stress and age related diseases.
My lab will investigate how molecules, circuits and neuronal ensemble activity influence plasticity of excitatory and inhibitory synapses. We will study these mechanisms in neurons of sensory and association cortices in the context of memory storage, and how they are disrupted in genetically tractable mouse models of disease. To achieve this we will use a variety of state of the art approaches, such as single neuron genetic manipulations, in vivo synaptic labeling and multi-color two photon imaging.
Courtesy and Adjunct Professors
- Abdulbaki Agbas, Ph.D. - Adjunct Assistant Professor - Dept. of Biochemistry, Kansas City University of Medicine and Biosciences
- Ken Audus, Ph.D. - Courtesy Professor - School of Pharmacy
- Marco Bortolato, Ph.D. - Adjunct Associate Professor - College of Pharmacy, University of Utah
- George Brenner, Ph.D. - Adjunct Professor - Oklahoma State University
- Alexander Moise, Ph.D. - Adjunct Associate Professor - Northern Ontario School of Medicine
- Julie S. Nagel, Ph.D. - Courtesy Assistant Professor – Research and Graduate Studies
- Asma Zaidi, Ph.D. - Adjunct Associate Professor - Dept. of Biochemistry, Kansas City University of Medicine and Biosciences