- 2007 B.S. Hunan University of Science and Technology
- 2010 M.S. Zhengzhou University
- 2008 - 2010 Joint Graduate Student, Shanghai Institute of Meteria Medica, China Academy of Science
Pregnane x receptor (PXR, NR1I2) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. PXR is activated by a large number of drugs and xenobiotics that serve as direct ligands for this promiscuous receptor. Patients undergoing pharmacotherapy with the antibiotic rifampicin can exhibit compromised immune-responses in liver and intestine. SUMOylation, as one of the post-translational modification of PXR, is thought to play a pivotal role in mediating the anti-inflammatory effects of PXR ligands such as rifampicin. My current research is focused on identifying ligand- and inflammation-induced post-translational modification of human PXR using mass spectrometry.