Ranu Pal

Research Associate
Primary office:
785-864-3413


Publications

  1. Xiaodong Bao, Ranu Pal, Kevin N. Hascup, Yongfu Wang, Wen-Tung Wang, Wenhao Xu, Dongwei Hui, Abdulbaki Agbas, Xinkun Wang, Mary L. Michaelis, In-Young Choi, Andrei B. Belousov, Greg A. Gerhardt, and Elias K. Michaelis. Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability. The Journal of Neuroscience, 29(44):13929-13944. 2009.
  2. Xinkun Wang, Asma Zaidi, Ranu Pal, Alexander S Garrett, Rogelio Braceras, Xue-wen Chen, Mary L Michaelis and Elias K Michaelis. Genomic and Biochemical Approaches in the Discovery of Mechanisms for Selective Neuronal Vulnerability to Oxidative Stress. BMC Neuroscience, 10:12, Page 1-20. 2009.
  3. Dongwei Hui, Keshava N. Kumar, Julie R. Mach, Ashik Srinivasan, Ranu Pal, Xiaodong Bao, Abdulbaki Agbas, Georg Höfner, Klaus T. Wanner, and Elias K. Michaelis. A Rat Brain Bicistronic Gene with an Internal Ribosome Entry Site Codes for a Phencyclidine-binding Protein with Cytotoxic Activity. Journal of Biological Chemistry, 284: 2245-2257. 2008.
  4. Wang, X. Pal, Ranu, Chen, Xue-wen, Kumar, Keshava.N., Kim, Ok -Jin, Michaelis, Elias K. Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus. Genomics. 90:201-212, 2007.
  5. Ranu Pal, Derek B. Oien, Fatma Y. Ersen, and Jackob Moskovitz. Elevated level of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse. Experimental Brain Research 180:765-774, 2007.
  6. Wang, X., Pal, R., Chen, X-W., Limpeanchob, N., Kumar, K., and Michaelis, E. High Intrinsic Oxidative Stress May Underlie Selective Vulnerability of the Hippocampal CA1 region. Mol. Brain Res. 140:120-126, 2005.
  7. Pal, Ranu, Agbas, Abdulbaki, Bao, Xiaodong, Hui, Dongwei, Leary, Cynthia, Hunt, John, Naniwadekar, Ashutosh, Michaelis, Mary L., Kumar, Keshava N., and Michaelis, Elias K. Selective Dendrite-Targeting of mRNAs of NR1 Splice Variants without exon 5: Identification of a cis-acting Sequence and Isolation of Sequence-Binding Proteins. Brain Research 994(1): 1-18, 2003.
  8. Pal, R., Eaton, M.J., Islam, S, Hake-Friendscho, M., Kumar, K.N., and Michaelis, E.K. Immunocytochemical and in situ hybridization studies of the expression and distribution of three subunits of a complex with NMDA Receptor-like properties. Neuroscience 94(4): 1291-1311, 1999.
  9. Kumar, K.N., Johnson, P.S., Chen, X., Pal, R., Ahmad, M., Ragland, T., Bigge, C., and Michaelis, E.K. Cloning of a brain N-Methyl-D-Aspartate and D,L-∈-2-Amino-4-propyl-5-phosphono-3-pentanoic acid(CGP 39653)-Binding Protein. Biochemical and Biophysical Res. Commun. 253: 463-469, 1998.
  10. Michaelis, M.L., Walsh, J., Pal, R., Hurlbert, M., Hoel, G., Bland, K., Foye, J., and Kyong, J. Immunologic and kinetic characterization of the Na+/Ca++ exchanger in neuronal and non-neuronal cells. Brain Res. 661: 104-116, 1994.
  11. Eggeman, K.T., Pal, R., Walsh, J., Kumar, K.N., and Michaelis, E.K. Immunochemical and immunohistochemical characterization of a synaptic membrane that binds the competitive antagonists of NMDA receptors. Neuroscience Letts. 158: 173-176, 1993.
  12. Michaelis, M. L., Walsh, J. and Pal, R. Immunohistochemical analysis of the 36 kDA-synaptic membrane Na+/Ca++ exchanger in rat brain. J. Neurochem. 61: S217, 1993.

Research Interests

A. Glutamate neurotransmission in CNS-Glutamate is the major and most important excitatory neurotransmitter in CNS. Release of excess amount of glutamate in the extra cellular areas leads to excitotoxicity and cell death and has been associated with a number of acute and chronic neurodegenerative diseases such as Parkinson's, ALS, MS, Schizophrenia and even Alzheimer's. Glutamate also plays an important role in age-associated changes in neuronal and synapse loss of some select regions specially hippocampus of adult brain. Considering the tremendous role that Glutamate plays in several pathological conditions, our group has created a transgenic mouse model of hyper-GLUD activity by expressing the Glutamate Dehydrogenase (GLUD1) gene in neurons. My interests are focused to characterize in this newly-generated mouse the distribution and mapping of some of the important proteins associated with over-expression of GLUD1 that result in excess amount of Glu release at nerve endings and leads to synaptic dysfunction and selective vulnerability.

B. Oxidative Stress and nitrotyrosine---There is a definitive link between oxidative stress and nitrotyrosine. Protein nitration, can be detected by Nitrotyrosine, a specific marker for oxidative damage and is caused by peroxynitrite. The role of peroxynitrite has been linked to a number of neurodegenerative diseases such as AD, ALS etc. Currently I am working closely on a project involving a derivatized nitrotyrosine compound of Dr. Schoneich's group of Pharmaceutical chemistry that could help us determining the cells/regions of the brain which are involved in oxidative stress.

Education

  • Post-Doctoral -1986-1989, Univ. of Calcutta, West Bengal, India.
  • Ph.D-Zoology, 1982, Univ. of Burdwan, West Bengal, India.
  • MS---Zoology, 1975, Univ. of Burdwan, West Bengal, India.

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